COMPANY PROFILE

 NameUniversità degli Studi di Palermo
 RegionSicily
StatusUniversity

 
 PROPOSAL 

TitlePreparation of 4,5,6,9-tetrahydropyrrolo[2',3':3,4]cyclohepta[1,2-d] oxazoles and their use as anticancer agents
Project id.66
Reference sectorBIOTECHNOLOGY
IP Protection LevelPatent procedure is ongoing
Description of the innovation projectA series of 26 compounds of the new ring system was synthesized and screened at the NCI of Bethesda on a panel of 60 human cell lines divided into 9 subpanels (breast, ovaries, lung, colon, CNS, melanoma, leukemia, kidney, prostate. Six compounds showed growth inhibitory activity against on the totality of the NCI cell lines reaching the nanomolar range, especially against the MDA-MB-435 cell line of melanoma and the A498 cell line of renal cancer subpanels (GI50 values of 19 and 20 nM, respectively).
State of dev.Patent
Industrial applicationIn vivo test will be necessary to the clinical development of the best derivatives, even after further structural modifications in order to improve the farmokinetic profile.
Market segmentConsidering the novelty in the chemical stucture, and the broad range of activity of the possible drug as antitumor agent, it can be hypotheiszed a market of million dollars per year.
Advantage factorConsidering the novelty in the chemical stucture, and the broad range of activity of the possible drug as antitumor agent, it can be hypotheiszed a market of million dollars per year.
Commercial challengeIn vivo test will be necessary to the clinical development of the best derivatives, even after further structural modifications in order to improve the farmokinetic profile.
Publications and Customer Referecesno publications